Digital design and 3D-printed customized flanged cups in hip revision with severe acetabular bone defects / 中华骨科杂志

Objective:To investigate the effect of 3D-printed customized flanged cup in hip revision with severe acetabular bone defects.Methods:Since February 2017, 10 cases of 3D-printed customized flanged cups were used in hip revision with severe acetabular bone defects, including 2 cases of Paprosky type IIIA and 8 cases of Paprosky type IIIB. There were 5 males and 5 females, mean age 73.6±8.1 yrs (range, 62-87 yrs), 5 left and 5 right cases. The preoperative thin-layer CT scan was preformed to reverse reconstruct digital pelvis. Five cases of one-piece flanged cups and 5 cases of decomposed flanged cups, including 3 cases of composite one-piece cups were designed by computer. The surgery was performed strictly according to the plan.Postoperative follow-up was performed to evaluate the Harris score. Operation time,intraoperative bleeding and other complications such as vascular and nerve injury, postoperative infection, and dislocation were counted. Pelvic X-ray was used to assess the height and horizontal position of the center of rotation and the stability of the prosthesis.Results:The surgical procedure was successful, with an average operative time of 147.9±48.3 min (range, 96-212 min) and an average intraoperative bleeding of 730.4±262.6 ml (range, 500-1 300 ml). The mean time of final follow-up was 40.8±18.7 months (range, 16-70 months) after surgery. At the last follow-up, the average Harris score was 83.80±6.73, with 4 cases excellent, 5 cases good, and 1 case fair. The excellent and good rate was 90%. The last Harris score was significantly higher than that before operation 28.60±8.40 ( t=16.84, P<0.001). The height of affected hip joint rotation center decreased from 46.24±7.74 mm before operation to 15.54±2.54 mm after operation with significant difference ( t=14.61, P<0.001). It was slightly higher than the opposite side (13.81±1.48 mm), which had no significant difference ( t=1.83, P=0.100). The horizontal distance of affected hip joint rotation center increased from 33.79±5.27 mm before operation to 40.53±4.50 mm after operation with significant difference ( t=3.62, P=0.006). It had no significant difference ( t=1.28, P=0.232) compared with the opposite side (38.54±3.46 mm). All incisions were healed in one stage without infection, vascular or nerve injury. During the following-up, all prostheses were in satisfied position without loosening, dislocation or screw breaks. Conclusion:Digitally assisted 3D-printed flanged cups can be used in hip revision with severe acetabular bone defect. It can not only improve hip joint function, but also restore the acetabular rotation center and the prosthesis stability, which can achieve good early and mid-term effect.

Individualized design of facial artery perforator flap for reconstruction of soft tissue defects in the midface / 中华医学美学美容杂志

Objective@#To explore the clinical application of individualized design of facial artery perforator flap for the repair of midfacial defect caused by tumor resection.@*Methods@#From January 2015 to January 2018, a total of 36 cases of midfacial defect were repaired by individualized designed facial artery. Flaps were designed and harvested according to the location and size of the midfacial defect resulted from tumor resection, including propeller flaps, droplet flaps and swallowtail-shape flaps. Flap size was between 1.3 cm × 1.6 cm and 2.0 cm × 4.2 cm with the donor site being sutured in the first stage.@*Results@#During the 6 months to 3 years of postoperative follow-up, no tumor recurred. All the 36 cases of individualized designed facial artery perforator flaps survived well. Furthermore, flaps being designed according to the wound defect had a good appearance, the flaps matched the color and texture of the surrounding skin and had a favorable appearance. Besides, flaps had a certain degree of sensory recovery while there was no obvious scarring presented in the donor area.@*Conclusions@#Individualized design of facial artery perforator flap has great advantages of simple and flexible, easy manipulation, reliable flap blood flow and minimal donor injury, which render it valuable for clinical application.

Effect of two different kits on blood concentration of tacrolimus in liver transplantation / 中国生化药物杂志

Objective To investigate the effect of two different detection methods of reagent kits on blood concentration of Tacrolimus in liver transplantation .Methods 81 cases of liver transplantation patients received Tacrolimus testing in Zhoushan Hospital from February 2013 to August 2016 were selected, fasting venous blood of upper limb were collected 12h after treatment, blood concentrations of Tacrolimus in whole blood samples were detected by Enzyme linked immunosorbent assay ( ELISA) kit and Enzyme enhanced immunoassay ( EMIT) kit respectively , the results of the two methods were observed and compared .Results The intra day and inter day precision and accuracy of ELISA method were good , RSD <5%, in the low concentration range , the precision of detection was slightly worse; the intraday and inter day precision and accuracy of ELISA method were good , RSD <5%, in the low concentration range , the precision of detection was slightly worse; the Tacrolimus blood concentration measured by ELISA (5.19 ±0.73) μg/L test kit was significantly lower than that measured by EMIT kit (8.29 ±1.14) μg/L, the difference was statistically significant (P<0.05); correlation coefficient of the detection results of two kinds of reagent kit was r =0.9176, the detection results were positively related; the determination results of ELISA kit ( 1.116 ±0.125 ) μg/L were obviously lower than that of EMIT kit (1.507 ±0.201) μg/L when Tacrolimus blood concentration <2g/L, with significant difference (P<0.05).Conclusion ELISA detection kit and EMIT kit can be used to monitor the blood concentration of Tacrolimus in liver transplantation patients , and the correlation was good, but the blood concentrations of Tacrolimus were significantly different between the two kits , need to establish their own of therapeutic window to judge,the test results can not be replaced with each other .

Long-term efficacy of intense pulsed light on epilation / 中华医学美学美容杂志

Objective To evaluate the long-term effects and safety of an intense pulsed light (IPL) in the treatment of epilation.Methods 159 patients received treatment with a non-coherent IPL because of unwanted facial and body hair.116 cases were followed up by means of phone call or letters.The average follow-up time was 38 months.Results Overall,36 (31.0％) patients were very satisfied,53 (45.7％) were satisfied and 27 (23.3％) remained unsatisfied with the outcome of lightassisted hair removal.The non-coherent intense pulsed light satisfactorily removed unwanted dark hair.Hair-free periods from weeks to years could be observed.Besides,the satisfaction was not related with the colour of the skin.Conclusions Hair removal by a non-coherent intense pulsed light is an effective and safe method for long-term epilation of unwanted hair.

Study on classification of medical devices / 中国医疗器械杂志

In this paper, some main classification methods are analyzed in detail and some issues need to be further discussed are put forward.

Efficacy and safety of Qianliejiedu capsule in the treatment of chronic prostatitis / 中华泌尿外科杂志

Objective To evaluate the efficacy and safety of Qianliejiedu capsule in the treatment of chronic prostatitis. Methods A multi-central,randomized,double-blind clinical trial was conducted.A total of 209 patients diagnosed as chronic prostatitis were randomly divided into two groups:the trial group were treated with Qianliejiedu Capsule,5 pills were taken orally for each time,twice a day;the control group were given Qianlietai Pill,5 pills were taken orally for each time and 3 times a day.All patients of the tWO groups were treated for 4 weeks,The efficacy was evaluated by urethra irritating,painful or discomfortable symptoms,and the WBC count in EPS after the treatment.Clinical criteria divided into 4 types,cure:symptom score compared with a decrease≥90%;markedly effective:symptom score compared with a decrease of 60%to 89%;effective:symptom score comparedwith a decrease of 30%to 59%;invalid:symptom score compared with a decrease of＜30%.Results There were 102 patients in the treatment group,11 got cured,49 cases were remarkably effectire,28 eases were effective,14 eases were ineffective and the total effective rate was 86.2%(88/102).There were 98 patients in the treatment group,4 got cured,38 cases were remarkably effective,35 cases were effective,21 cases were ineffective,and the total effective rate was 78.6%(77/98).The trial group and the control group could improve the symptoms such as frequent micturition,the remaining urine,the lower abdomen ache,the urethra stabbing pain,the unwell perineum,the waist and sacrum ache,the moist scrotum,and the testicle ache.The vanishing rate of the trial group was 87.6%,82.1%,74.5%,84.1%,93.7%,80.3%,82.5%,82.3%;and the control group was 74.7%,73.0%,71.0%,74.2%,71.4%,67.9%,72.3%,76.2%.The vanishing rates of frequent micturition symptom of the 2 groups were significantly different(P=0.032).The result of WBC of the trial group before treatment was as follows:WBC 10-19 28 cases,WBC 20-29 33 cases,WBC≥30 41 cases.The result of WBC of the trial group after treatment was as follows:WBC＜10 45cases,WBC 10-19 34 cases,WBC 20-29 20 cases,WBC≥30 3 cases.The result of WBC of the control group before treatment was as follows:WBC 10-19 26 cases,WBC 20-29 35 cases,WBC:≥30 37 cases.The result of WBC of the control group after treatment was as follows:WBC＜10 42 caaes,WBC 10-19 33 cases,WBC 20-29 15 cases,WBC≥30 8 cases.There were significant differences between the before and after treatment results(P＜0.05).Two cases in the trial group and 3 cases in the control group had mild adverse reactions such as nausea,epigastric discomfort,and watery stool. Conclusion Qianliejiedu capsule is effective and safe for the treatment of chronic prostatitis.

Treatment of enchondroma of the hand with porous calcium phosphate bone bioceramic / 中国矫形外科杂志

[Objective]To report the results of treatment of enchondroma of the hand with curettage and porous bioceramic bone grafting. [Methods]Fifteen patients with digital enchondroma were reviewed.The average follow-up period was 30 months.The final function and radiographic appearance of the surgically treated digits were analyzed.[Results]At final evaluation the bony incorporation was uneventful in all patients.The mean functional Muskuloskeletal Tumor Society Score was 29.Radiographs showed apparent partial absorption of bioceramic bone in only two patients.All digits achieved full range of motion after surgery.No complication was found.[Conclusion]Porous bioceramic bone is safe and effective as a bone-filling substance after curettage of enchondroma of the hand.